USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: PSB6_HUMAN USC-OGP 2-DE database:  PSB6_HUMAN PSB6_HUMAN General information about the entry View entry in simple text format Entry name PSB6_HUMAN Primary accession number P28072 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Proteasome subunit beta type-6; EC=3.4.25.1 {ECO:0000269|PubMed:27176742}; AltName: Full=Macropain delta chain; AltName: Full=Multicatalytic endopeptidase complex delta chain; AltName: Full=Proteasome delta chain; AltName: Full=Proteasome subunit Y; Flags: Precursor;. Gene name Name=PSMB6 Synonyms=LMPY, Y Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-5 {PLATELET 4-5} Homo sapiens (Human)   map experimental info   PLATELET_4-5 MAP LOCATIONS: SPOT OGP-0206: pI=4.71; Mw=23744 SPOT OGP-0207: pI=4.85; Mw=23562 SPOT OGP-0217: pI=4.87; Mw=21103 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1299: pI=4.88; Mw=23684 Cross-references UniProtKB/Swiss-Prot P28072; PSB6_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name PSB6_HUMAN Primary accession number P28072 Secondary accession number(s) Q96J55 Sequence was last modified on  May 10, 2002 (version 4) Annotations were last modified on  March 15, 2017 (version 186) Name and origin of the protein Description RecName: Full=Proteasome subunit beta type-6; EC=3.4.25.1 {ECO:0000269|PubMed:27176742}; AltName: Full=Macropain delta chain; AltName: Full=Multicatalytic endopeptidase complex delta chain; AltName: Full=Proteasome delta chain; AltName: Full=Proteasome subunit Y; Flags: Precursor; Gene name Name=PSMB6 Synonyms=LMPY, Y Encoded on Name=PSMB6; Synonyms=LMPY, Y Keywords 3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Host-virus interaction; Hydrolase; Nucleus; Phosphoprotein; Polymorphism; Protease; Proteasome; Reference proteome; Threonine protease; Zymogen. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL D29012; BAA06098.1; -; mRNA EMBL BC000835; AAH00835.1; -; mRNA EMBL X61971; CAA43963.1; -; mRNA CCDS CCDS11056.1; -; . PIR B54589; B54589; . PIR S17522; S17522; . RefSeq NP_002789.1; NM_002798.2; . UniGene Hs.77060; -; . PDB 4R3O; X-ray; 2.60 A; H/V=35-236 PDB 4R67; X-ray; 2.89 A; H/V/j/x=35-236 PDB 5A0Q; EM; 3.50 A; H/V=35-239 PDB 5GJQ; EM; 4.50 A; a/o=1-239 PDB 5GJR; EM; 3.50 A; a/o=1-239 PDB 5L4G; EM; 4.02 A; 6/Z=1-239 PDB 5LE5; X-ray; 1.80 A; N/b=35-239 PDB 5LEX; X-ray; 2.20 A; N/b=35-239 PDB 5LEY; X-ray; 1.90 A; N/b=35-239 PDB 5LEZ; X-ray; 2.19 A; N/b=35-239 PDB 5LF0; X-ray; 2.41 A; N/b=35-239 PDB 5LF1; X-ray; 2.00 A; N/b=35-239 PDB 5LF3; X-ray; 2.10 A; N/b=36-239 PDB 5LF4; X-ray; 1.99 A; N/b=35-239 PDB 5LF6; X-ray; 2.07 A; N/b=35-239 PDB 5LF7; X-ray; 2.00 A; N/b=35-239 PDB 5T0C; EM; 3.80 A; AN/BN=2-239 PDB 5T0G; EM; 4.40 A; N=2-239 PDB 5T0H; EM; 6.80 A; N=2-239 PDB 5T0I; EM; 8.00 A; N=2-239 PDB 5T0J; EM; 8.00 A; N=2-239 PDBsum 4R3O; -; . PDBsum 4R67; -; . PDBsum 5A0Q; -; . PDBsum 5GJQ; -; . PDBsum 5GJR; -; . PDBsum 5L4G; -; . PDBsum 5LE5; -; . PDBsum 5LEX; -; . PDBsum 5LEY; -; . PDBsum 5LEZ; -; . PDBsum 5LF0; -; . PDBsum 5LF1; -; . PDBsum 5LF3; -; . PDBsum 5LF4; -; . PDBsum 5LF6; -; . PDBsum 5LF7; -; . PDBsum 5T0C; -; . PDBsum 5T0G; -; . PDBsum 5T0H; -; . PDBsum 5T0I; -; . PDBsum 5T0J; -; . ProteinModelPortal P28072; -; . SMR P28072; -; . BioGrid 111667; 83; . DIP DIP-33847N; -; . IntAct P28072; 24; . MINT MINT-5004163; -; . STRING 9606.ENSP00000270586; -; . BindingDB P28072; -; . ChEMBL CHEMBL1944496; -; . MEROPS T01.010; -; . iPTMnet P28072; -; . PhosphoSitePlus P28072; -; . SwissPalm P28072; -; . BioMuta PSMB6; -; . DMDM 20532407; -; . OGP P28072; -; . SWISS-2DPAGE P28072; -; . EPD P28072; -; . PaxDb P28072; -; . PeptideAtlas P28072; -; . PRIDE P28072; -; . DNASU 5694; -; . Ensembl ENST00000270586; ENSP00000270586; ENSG00000142507; . GeneID 5694; -; . KEGG hsa:5694; -; . CTD 5694; -; . DisGeNET 5694; -; . GeneCards PSMB6; -; . HGNC HGNC:9543; PSMB6; . HPA HPA023312; -; . HPA HPA063656; -; . MIM 600307; gene; . neXtProt NX_P28072; -; . OpenTargets ENSG00000142507; -; . PharmGKB PA33888; -; . eggNOG KOG0174; Eukaryota; . eggNOG ENOG410XS23; LUCA; . GeneTree ENSGT00510000046484; -; . HOGENOM HOG000091079; -; . HOVERGEN HBG000123; -; . InParanoid P28072; -; . KO K02738; -; . OMA TSIMAVQ; -; . OrthoDB EOG091G0GUI; -; . PhylomeDB P28072; -; . TreeFam TF106221; -; . Reactome R-HSA-1169091; Activation of NF-kappaB in B cells; . Reactome R-HSA-1234176; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; . Reactome R-HSA-1236974; ER-Phagosome pathway; . Reactome R-HSA-1236978; Cross-presentation of soluble exogenous antigens (endosomes); . Reactome R-HSA-174084; Autodegradation of Cdh1 by Cdh1:APC/C; . Reactome R-HSA-174113; SCF-beta-TrCP mediated degradation of Emi1; . Reactome R-HSA-174154; APC/C:Cdc20 mediated degradation of Securin; . Reactome R-HSA-174178; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; . Reactome R-HSA-174184; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; . Reactome R-HSA-180534; Vpu mediated degradation of CD4; . Reactome R-HSA-180585; Vif-mediated degradation of APOBEC3G; . Reactome R-HSA-187577; SCF(Skp2)-mediated degradation of p27/p21; . Reactome R-HSA-195253; Degradation of beta-catenin by the destruction complex; . Reactome R-HSA-202424; Downstream TCR signaling; . Reactome R-HSA-211733; Regulation of activated PAK-2p34 by proteasome mediated degradation; . Reactome R-HSA-2467813; Separation of Sister Chromatids; . Reactome R-HSA-2871837; FCERI mediated NF-kB activation; . Reactome R-HSA-349425; Autodegradation of the E3 ubiquitin ligase COP1; . Reactome R-HSA-350562; Regulation of ornithine decarboxylase (ODC); . Reactome R-HSA-382556; ABC-family proteins mediated transport; . Reactome R-HSA-450408; AUF1 (hnRNP D0) binds and destabilizes mRNA; . Reactome R-HSA-4608870; Asymmetric localization of PCP proteins; . Reactome R-HSA-4641257; Degradation of AXIN; . Reactome R-HSA-4641258; Degradation of DVL; . Reactome R-HSA-5358346; Hedgehog ligand biogenesis; . Reactome R-HSA-5362768; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; . Reactome R-HSA-5607761; Dectin-1 mediated noncanonical NF-kB signaling; . Reactome R-HSA-5607764; CLEC7A (Dectin-1) signaling; . Reactome R-HSA-5610780; Degradation of GLI1 by the proteasome; . Reactome R-HSA-5610783; Degradation of GLI2 by the proteasome; . Reactome R-HSA-5610785; GLI3 is processed to GLI3R by the proteasome; . Reactome R-HSA-5632684; Hedgehog 'on' state; . Reactome R-HSA-5658442; Regulation of RAS by GAPs; . Reactome R-HSA-5668541; TNFR2 non-canonical NF-kB pathway; . Reactome R-HSA-5676590; NIK-->noncanonical NF-kB signaling; . Reactome R-HSA-5678895; Defective CFTR causes cystic fibrosis; . Reactome R-HSA-5687128; MAPK6/MAPK4 signaling; . Reactome R-HSA-5689603; UCH proteinases; . Reactome R-HSA-5689880; Ub-specific processing proteases; . Reactome R-HSA-68827; CDT1 association with the CDC6:ORC:origin complex; . Reactome R-HSA-68949; Orc1 removal from chromatin; . Reactome R-HSA-69017; CDK-mediated phosphorylation and removal of Cdc6; . Reactome R-HSA-69229; Ubiquitin-dependent degradation of Cyclin D1; . Reactome R-HSA-69481; G2/M Checkpoints; . Reactome R-HSA-69601; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; . Reactome R-HSA-8852276; The role of GTSE1 in G2/M progression after G2 checkpoint; . Reactome R-HSA-8854050; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; . Reactome R-HSA-983168; Antigen processing: Ubiquitination & Proteasome degradation; . ChiTaRS PSMB6; human; . GeneWiki PSMB6; -; . GenomeRNAi 5694; -; . PRO PR:P28072; -; . Proteomes UP000005640; Chromosome 17; . Bgee ENSG00000142507; -; . CleanEx HS_PSMB6; -; . ExpressionAtlas P28072; baseline and differential; . Genevisible P28072; HS; . GO GO:0005829; C:cytosol; IDA:HPA; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005654; C:nucleoplasm; IDA:HPA; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0000502; C:proteasome complex; IDA:UniProtKB; . GO GO:0005839; C:proteasome core complex; ISS:UniProtKB; . GO GO:0045296; F:cadherin binding; IDA:BHF-UCL; . GO GO:0004175; F:endopeptidase activity; NAS:UniProtKB; . GO GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW; . GO GO:0031145; P:anaphase-promoting complex-dependent catabolic process; TAS:Reactome; . GO GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I; TAP-dependent; TAS:Reactome GO GO:0038095; P:Fc-epsilon receptor signaling pathway; TAS:Reactome; . GO GO:0000165; P:MAPK cascade; TAS:Reactome; . GO GO:0090090; P:negative regulation of canonical Wnt signaling pathway; TAS:Reactome; . GO GO:0010972; P:negative regulation of G2/M transition of mitotic cell cycle; TAS:Reactome; . GO GO:0051436; P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome; . GO GO:0038061; P:NIK/NF-kappaB signaling; TAS:Reactome; . GO GO:0090263; P:positive regulation of canonical Wnt signaling pathway; TAS:Reactome; . GO GO:0051437; P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition; TAS:Reactome; . GO GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; TAS:Reactome; . GO GO:0016579; P:protein deubiquitination; TAS:Reactome; . GO GO:0000209; P:protein polyubiquitination; TAS:Reactome; . GO GO:0006521; P:regulation of cellular amino acid metabolic process; TAS:Reactome; . GO GO:0043488; P:regulation of mRNA stability; TAS:Reactome; . GO GO:0061418; P:regulation of transcription from RNA polymerase II promoter in response to hypoxia; TAS:Reactome; . GO GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; TAS:Reactome; . GO GO:0002223; P:stimulatory C-type lectin receptor signaling pathway; TAS:Reactome; . GO GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome; . GO GO:0055085; P:transmembrane transport; TAS:Reactome; . GO GO:0033209; P:tumor necrosis factor-mediated signaling pathway; TAS:Reactome; . GO GO:0016032; P:viral process; IEA:UniProtKB-KW; . GO GO:0060071; P:Wnt signaling pathway; planar cell polarity pathway; TAS:Reactome Gene3D 3.60.20.10; -; 1; . InterPro IPR029055; Ntn_hydrolases_N; . InterPro IPR000243; Pept_T1A_subB; . InterPro IPR016050; Proteasome_bsu_CS; . InterPro IPR001353; Proteasome_sua/b; . InterPro IPR023333; Proteasome_suB-type; . Pfam PF00227; Proteasome; 1; . PRINTS PR00141; PROTEASOME; . SUPFAM SSF56235; SSF56235; 1; . PROSITE PS00854; PROTEASOME_BETA_1; 1; . PROSITE PS51476; PROTEASOME_BETA_2; 1; .

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• SWISS-2DPAGE - The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
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